NCLEX Practice Test 2025 - Free NCLEX Practice Questions and Study Guide

In the context of a client recently prescribed lithium, it's essential to clarify the use of hydrochlorothiazide, which is a diuretic. Lithium has a narrow therapeutic index and is heavily influenced by electrolyte balance, particularly sodium levels. Hydrochlorothiazide can lead to increased sodium loss through diuresis, which can subsequently cause lithium levels to rise, potentially leading to toxicity.

While acetaminophen is commonly used for pain relief and does not have a direct interaction with lithium, the other medications can have more significant effects on the client's overall health, particularly in relation to lithium therapy. It's crucial for the healthcare provider to assess how hydrochlorothiazide may impact lithium levels and ensure appropriate monitoring and adjustments as needed.

Thus, verifying the safety of hydrochlorothiazide for a client on lithium is a priority to prevent complications from possible lithium toxicity.